Josh Zisson, attorney and cycling safety advocate, assembled "the safest bike on the road." It has a "city bike" style frame with upright riding position. Other features - enclosed drum brakes, internal-gear hub, puncture-resistant tires, chain guard, fenders. (I don't see those features as contributing significantly to safety, but they're rider-friendly.)
The bike also has some visibility features that do set it apart safety-wise. (Maybe I have too much faith in the goodness of humanity, but I believe essentially nobody will deliberately run into a bicyclist. If they don't see you, however, all bets are off.) LED headlight and daytime running lights powered by dynamo hub, a taillight that "gets brighter when the bike slows down" (interesting!). And my favorite feature - the Halo Coating reflective paint job. Good gracious, that's awesome! The whole bike glows in the light of somebody's headlamps! I'd definitely choose that paint if I had the option. (It looks sorta primer-gray in the daylight, so it might not appeal to image-conscious hipsters. But in any situation where the lighting is less than ideal, it seems to me it would greatly enhance visibility.)
More info and photos HERE.